Species ***Mycobacterium* *tuberculosis***

Name: Mycobacterium tuberculosis (Zopf 1883) Lehmann and Neumann 1896 (Approved Lists 1980)

Category: Species

Proposed as: comb. nov.

Basonym: "Bacterium tuberculosis" Zopf 1883

Etymology: L. neut. n. tuberculum, a small swelling, tubercle; N.L. fem. n. suff. -osis, suffix expressing state or condition, in medical terminology denoting a state of disease; N.L. gen. fem. n. tuberculosis, of tuberculosis

Gender: neuter

Type strain: ATCC 27294; H37Rv; NCTC 13114; NCTC 13144

Conduct genome-based taxonomy at

16S rRNA gene: MH794239 Analyse FASTA

Effective publication: Lehmann KB, Neumann R. Atlas und Grundriss der Bakteriologie und Lehrbuch der speziellen bakteriologischen Diagnostik, 1st ed. J.F. Lehmann, München, 1896.

IJSEM list: Skerman VBD, McGowan V, Sneath PHA. Approved lists of bacterial names. Int J Syst Bacteriol 1980; 30:225-420.

Nomenclatural status: validly published under the ICNP

Taxonomic status: correct name

Risk group: 3

Synonyms:

Name	Kind
Mycobacterium bovis subsp. caprae (Aranaz et al. 1999) Niemann et al. 2002	heterotypic synonym, validly published under the ICNP, distinct rank
"Bacterium tuberculosis" Zopf 1883	homotypic synonym, not validly published, basonym of name in Approved Lists
Mycobacterium microti Reed 1957 (Approved Lists 1980)	heterotypic synonym, validly published under the ICNP
Mycobacterium tuberculosis subsp. caprae Aranaz et al. 1999	heterotypic synonym, validly published under the ICNP, distinct rank
Mycobacterium africanum Castets et al. 1969 (Approved Lists 1980)	heterotypic synonym, validly published under the ICNP
Mycobacterium bovis Karlson and Lessel 1970 (Approved Lists 1980)	heterotypic synonym, validly published under the ICNP
Mycobacterium pinnipedii Cousins et al. 2003	heterotypic synonym, validly published under the ICNP
Mycobacterium caprae (Aranaz et al. 1999) Aranaz et al. 2003	heterotypic synonym, validly published under the ICNP

Emendations:
- Riojas et al. 2018 Riojas MA, McGough KJ, Rider-Riojas CJ, Rastogi N, Hazbon MH. Phylogenomic analysis of the species of the Mycobacterium tuberculosis complex demonstrates that Mycobacterium africanum, Mycobacterium bovis, Mycobacterium caprae, Mycobacterium microti and Mycobacterium pinnipedii are later heterotypic synonyms of Mycobacterium tuberculosis. Int J Syst Evol Microbiol 2018; 68:324-332. Oren A, Garrity GM. Notification list. Notification that new names and new combinations have appeared in volume 68, part 1 of the IJSEM. Int J Syst Evol Microbiol 2018; 68:979-981.
  Notes:
  - 🫂 Emendation accompanied by 5 proposals regarding the synonymy of the species.

Notes:
- 🥇 Nomenclatural type of the genus Mycobacterium Lehmann and Neumann 1896 (Approved Lists 1980). Publication: Lehmann KB, Neumann R. Atlas und Grundriss der Bakteriologie und Lehrbuch der speziellen bakteriologischen Diagnostik, 1st ed. J.F. Lehmann, München, 1896.
- ⏰ According to Riojas et al. (2018), this species is an earlier heterotypic synonym of Mycobacterium africanum Castets et al. 1969 (Approved Lists 1980). Publication: Riojas MA, McGough KJ, Rider-Riojas CJ, Rastogi N, Hazbon MH. Phylogenomic analysis of the species of the Mycobacterium tuberculosis complex demonstrates that Mycobacterium africanum, Mycobacterium bovis, Mycobacterium caprae, Mycobacterium microti and Mycobacterium pinnipedii are later heterotypic synonyms of Mycobacterium tuberculosis. Int J Syst Evol Microbiol 2018; 68:324-332.
- ⏰ According to Riojas et al. (2018), this species is an earlier heterotypic synonym of Mycobacterium bovis Karlson and Lessel 1970 (Approved Lists 1980). Publication: Riojas MA, McGough KJ, Rider-Riojas CJ, Rastogi N, Hazbon MH. Phylogenomic analysis of the species of the Mycobacterium tuberculosis complex demonstrates that Mycobacterium africanum, Mycobacterium bovis, Mycobacterium caprae, Mycobacterium microti and Mycobacterium pinnipedii are later heterotypic synonyms of Mycobacterium tuberculosis. Int J Syst Evol Microbiol 2018; 68:324-332.
- ⏰ According to Riojas et al. (2018), this species is an earlier heterotypic synonym of Mycobacterium caprae (Aranaz et al. 1999) Aranaz et al. 2003. Publication: Riojas MA, McGough KJ, Rider-Riojas CJ, Rastogi N, Hazbon MH. Phylogenomic analysis of the species of the Mycobacterium tuberculosis complex demonstrates that Mycobacterium africanum, Mycobacterium bovis, Mycobacterium caprae, Mycobacterium microti and Mycobacterium pinnipedii are later heterotypic synonyms of Mycobacterium tuberculosis. Int J Syst Evol Microbiol 2018; 68:324-332.
- ⏰ According to Riojas et al. (2018), this species is an earlier heterotypic synonym of Mycobacterium microti Reed 1957 (Approved Lists 1980). Publication: Riojas MA, McGough KJ, Rider-Riojas CJ, Rastogi N, Hazbon MH. Phylogenomic analysis of the species of the Mycobacterium tuberculosis complex demonstrates that Mycobacterium africanum, Mycobacterium bovis, Mycobacterium caprae, Mycobacterium microti and Mycobacterium pinnipedii are later heterotypic synonyms of Mycobacterium tuberculosis. Int J Syst Evol Microbiol 2018; 68:324-332.
- ⏰ According to Riojas et al. (2018), this species is an earlier heterotypic synonym of Mycobacterium pinnipedii Cousins et al. 2003. Publication: Riojas MA, McGough KJ, Rider-Riojas CJ, Rastogi N, Hazbon MH. Phylogenomic analysis of the species of the Mycobacterium tuberculosis complex demonstrates that Mycobacterium africanum, Mycobacterium bovis, Mycobacterium caprae, Mycobacterium microti and Mycobacterium pinnipedii are later heterotypic synonyms of Mycobacterium tuberculosis. Int J Syst Evol Microbiol 2018; 68:324-332.
- 🏢 Synonymy of this taxon was mentioned in an IJSEM list. Publication: Oren A, Garrity GM. Notification list. Notification that new names and new combinations have appeared in volume 68, part 1 of the IJSEM. Int J Syst Evol Microbiol 2018; 68:979-981.
- 😷 The risk group for Belgium has been imported on 2024-02-05. The full classification is: risk group = 3, note = "avium: 2 human and animal pathogen - human risk group: 2 - animal risk group: 3 - biological class of risk animal: 3; typus gallinaceus: 2 human and animal pathogen - human risk group: 2 - animal risk group: 3 - biological class of risk animal: 3; default: 3 human and animal pathogen - biological class of risk animal: 3; variant tuberculosis: 3 human and animal pathogen - biological class of risk animal: 3; typus humanus: 3 human and animal pathogen - biological class of risk animal: 3; var. hominis: 3 human and animal pathogen - biological class of risk animal: 3; complex: 3 human and animal pathogen - biological class of risk animal: 3; variant africanum: 3 human and animal pathogen - biological class of risk animal: 3; variant bovis: 3 human and animal pathogen - biological class of risk animal: 3; typus bovinus: 3 human and animal pathogen - biological class of risk animal: 3; var. bovis: 3 human and animal pathogen - biological class of risk animal: 3; variant bovis BCG: 2 human and animal pathogen - biological class of risk animal: 2; variant caprae: 3 human and animal pathogen - human risk group: 3 - animal risk group: 3 - biological class of risk animal: 2; variant microti: 3 human pathogen - (*); var. muris: 3 human pathogen - (*); variant pinnipedii: 3 human and animal pathogen - human risk group: 3 - animal risk group: 3 - biological class of risk animal: 2". — The risk group for Canada has been imported on 2024-02-27. The full classification is: risk group = 3, note = "MC2 6020: 2 Animal classification RG: 1 - Security sensitive biological agent: No - Terrestrial animal pathogen under Canadian Food Inspection Agency authority: No - Containment level: Containment Level 2; complex: 3 Animal classification RG: 3 - Security sensitive biological agent: No - Terrestrial animal pathogen under Canadian Food Inspection Agency authority: No - Containment level: Containment Level 3 - Considerations for containment: Controlled activities with M. pinnipedii are to be carried out in accordance with the Biosafety Directive for Mycobacterium tuberculosis complex https://www.canada.ca/en/public-health/services/laboratory-biosafety-biosecurity/biosafety-directive-mycobacterium-tuberculosis-complex-mtbc.html; typus bovinus: 3 Animal classification RG: 3 - Security sensitive biological agent: No - Terrestrial animal pathogen under Canadian Food Inspection Agency authority: No - Containment level: Containment Level 3 - Considerations for containment: Controlled activities with M. bovis are to be carried out in accordance with the Biosafety Directive for Mycobacterium tuberculosis complex https://www.canada.ca/en/public-health/services/laboratory-biosafety-biosecurity/biosafety-directive-mycobacterium-tuberculosis-complex-mtbc.html; var. bovis: 3 Animal classification RG: 3 - Security sensitive biological agent: No - Terrestrial animal pathogen under Canadian Food Inspection Agency authority: No - Containment level: Containment Level 3 - Considerations for containment: Controlled activities with M. bovis are to be carried out in accordance with the Biosafety Directive for Mycobacterium tuberculosis complex https://www.canada.ca/en/public-health/services/laboratory-biosafety-biosecurity/biosafety-directive-mycobacterium-tuberculosis-complex-mtbc.html; MC2 6230: 2 Animal classification RG: 2 - Security sensitive biological agent: No - Terrestrial animal pathogen under Canadian Food Inspection Agency authority: No - Containment level: Containment Level 2; MC2 6030: 2 Animal classification RG: 2 - Security sensitive biological agent: No - Terrestrial animal pathogen under Canadian Food Inspection Agency authority: No - Containment level: Containment Level 2; default: 3 Animal classification RG: 3 - Security sensitive biological agent: No - Terrestrial animal pathogen under Canadian Food Inspection Agency authority: No - Containment level: Containment Level 3 - Considerations for containment: Controlled activities with M. tuberculosis are to be carried out in accordance with the Biosafety Directive for Mycobacterium tuberculosis complex https://www.canada.ca/en/public-health/services/laboratory-biosafety-biosecurity/biosafety-directive-mycobacterium-tuberculosis-complex-mtbc.html; typus humanus: 3 Animal classification RG: 3 - Security sensitive biological agent: No - Terrestrial animal pathogen under Canadian Food Inspection Agency authority: No - Containment level: Containment Level 3 - Considerations for containment: Controlled activities with M. tuberculosis are to be carried out in accordance with the Biosafety Directive for Mycobacterium tuberculosis complex https://www.canada.ca/en/public-health/services/laboratory-biosafety-biosecurity/biosafety-directive-mycobacterium-tuberculosis-complex-mtbc.html; var. hominis: 3 Animal classification RG: 3 - Security sensitive biological agent: No - Terrestrial animal pathogen under Canadian Food Inspection Agency authority: No - Containment level: Containment Level 3 - Considerations for containment: Controlled activities with M. tuberculosis are to be carried out in accordance with the Biosafety Directive for Mycobacterium tuberculosis complex https://www.canada.ca/en/public-health/services/laboratory-biosafety-biosecurity/biosafety-directive-mycobacterium-tuberculosis-complex-mtbc.html; Erdman: 3 Animal classification RG: 3 - Security sensitive biological agent: No - Terrestrial animal pathogen under Canadian Food Inspection Agency authority: No - Containment level: Containment Level 3; extensively drug resistant (XDR) strain: 3 Animal classification RG: 3 - Security sensitive biological agent: No - Terrestrial animal pathogen under Canadian Food Inspection Agency authority: No - Containment level: Containment Level 3 - Considerations for containment: Controlled activities with M. tuberculosis are to be carried out in accordance with the Biosafety Directive for Mycobacterium tuberculosis complex https://www.canada.ca/en/public-health/services/laboratory-biosafety-biosecurity/biosafety-directive-mycobacterium-tuberculosis-complex-mtbc.htm; R1Rv (TMC 205): 2 Security sensitive biological agent: No - Terrestrial animal pathogen under Canadian Food Inspection Agency authority: No - Containment level: Containment Level 2 - Considerations for containment: Prior to CBSG First Edition, additional operation procedures were required.; H37Ra: 2 Animal classification RG: 2 - Security sensitive biological agent: No - Terrestrial animal pathogen under Canadian Food Inspection Agency authority: No - Containment level: Containment Level 2; var. muris: 3 Animal classification RG: 3 - Security sensitive biological agent: No - Terrestrial animal pathogen under Canadian Food Inspection Agency authority: No - Containment level: Containment Level 3 - Considerations for containment: Controlled activities with M. microti are to be carried out in accordance with the Biosafety Directive for Mycobacterium tuberculosis complex https://www.canada.ca/en/public-health/services/laboratory-biosafety-biosecurity/biosafety-directive-mycobacterium-tuberculosis-complex-mtbc.html; H37Rv: 3 Animal classification RG: 3 - Security sensitive biological agent: No - Terrestrial animal pathogen under Canadian Food Inspection Agency authority: No - Containment level: Containment Level 3 - Considerations for containment: Controlled activities with M. tuberculosis are to be carried out in accordance with the Biosafety Directive for Mycobacterium tuberculosis complex https://www.canada.ca/en/public-health/services/laboratory-biosafety-biosecurity/biosafety-directive-mycobacterium-tuberculosis-complex-mtbc.html; MC2 6206: 2 Animal classification RG: 2 - Security sensitive biological agent: No - Terrestrial animal pathogen under Canadian Food Inspection Agency authority: No - Containment level: Containment Level 2". — The risk group for Swiss Confederation has been imported on 2024-02-01. The full classification is: risk group = 3. — The risk group for Germany has been imported on 2023-10-29. The full classification is: risk group = 3. — The risk group for France has been imported on 2024-08-30. The full classification is: risk group = 3, note = "complex: 3 V; default: 3 V". — The risk group for Sweden has been imported on 2024-02-05. The full classification is: risk group = 3, note = "V". — The risk group for United Kingdom has been imported on 2024-01-31. The full classification is: risk group = 3, note = "Vaccine available". — The risk group for United States has been imported on 2024-02-09. The full classification is: risk group = 3. — If in doubt, use the risk group given in the regulations for your country and, if these are not available, use the risk group given in the catalogue of the culture collection from which you have obtained or intend to obtain the strain.
- 🎓 Name mentioned 9999 times (maxed out) in PubMed until 2024-03-28.
- 🧍 According to Bartlett et al. (2022), this species is an established human pathogen. Publication: Bartlett A, Padfield D, Lear L, Bendall R, Vos M. A comprehensive list of bacterial pathogens infecting humans. Microbiology 2022; 168:0.
- 🧍 See also Weniger et al. (2010). Publication: Weniger T, Krawczyk J, Supply P, Niemann S, Harmsen D. MIRU-VNTRplus: a web tool for polyphasic genotyping of Mycobacterium tuberculosis complex bacteria. Nucleic Acids Res 2010; 38:W326-W331.
- 🧍 See also Weniger et al. (2012). Publication: Weniger T, Krawczyk J, Supply P, Harmsen D, Niemann S. Online tools for polyphasic analysis of Mycobacterium tuberculosis complex genotyping data: now and next. Infect Genet Evol 2012; 12:748-754.
- 🧍 The phylogenetic position of this species was determined in a genome-scale analysis by Nouioui et al. (2018). Publication: Nouioui I, Carro L, Garcia-Lopez M, Meier-Kolthoff JP, Woyke T, Kyrpides NC, Pukall R, Klenk HP, Goodfellow M, Goker M. Genome-Based Taxonomic Classification of the Phylum Actinobacteria. Front Microbiol 2018; 9:2007.

Subdivision:

Number of child taxa with a validly published and correct name: 0
Number of child taxa with a validly published name, including synonyms: 2
Total number of child taxa: 3

Child taxa:

Name	Nomenclatural status	Taxonomic status
Mycobacterium tuberculosis subsp. tuberculosis (Zopf 1883) Aranaz et al. 1999 (Approved Lists 1980)	validly published under the ICNP	synonym of its species (division into subspecies abandoned)
Mycobacterium tuberculosis subsp. caprae Aranaz et al. 1999	validly published under the ICNP	synonym
"Mycobacterium tuberculosis subsp. canetti" van Soolingen et al. 1997	not validly published	preferred name (not correct name)

Parent taxon: Mycobacterium Lehmann and Neumann 1896 (Approved Lists 1980)

Assigned by: Lehmann KB, Neumann R. Atlas und Grundriss der Bakteriologie und Lehrbuch der speziellen bakteriologischen Diagnostik, 1st ed. J.F. Lehmann, München, 1896.

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Record number: 778540

This LPSN page was printed on 2024-10-14 02:19:37

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Species Mycobacterium tuberculosis

Species ***Mycobacterium* *tuberculosis***